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How Climate Shapes India's Medically Most Relevant Snake’s Venom Chemistry

  • We assessed the influence of bioclimatic factors on the functional venom variation in Russell's viper (Daboia russelii).

  • Venoms (n=115) were sourced from varied biogeographies across >6600 km, followed by the functional characterisation of major toxins.

  • Models generated revealed the impact of historical climatic conditions on venom variability.

  • Phenotype maps that predict venom biochemistries of D. russelii across its range distribution were generated, providing valuable insights for deploying targeted therapies.

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In the Evolutionary Venomics Lab at the Centre for Ecological Sciences (CES), Indian Institute of Science (IISC), we investigate venomous animals and their venoms as model systems to address basic but broad questions in evolutionary biology and genetics. Using state-of-the-art technologies across multiple disciplines, we examine the fascinating evolutionary histories of the enigmatic lineages of venomous animals and their venoms.

 

A particular emphasis is placed on characterizing the composition, toxicity profiles and evolutionary dynamics of venoms of the ‘big four’ snakes in India, as the lab will strive to deliver advanced antivenom with a commensurate improvement in safety, specificity, and affordability of treatment. The protein composition, and hence the pathogenic potential of venoms, can exhibit dramatic geographical variation, with different populations of the same species having starkly distinct venom profiles and, consequently, resulting in a significantly reduced antivenom efficiency. Therefore, the lab will unravel intra- and interspecific venom variability in medically significant Indian snakes and utilize this information for the molecular design of effective snakebite therapy.

 

The other broad aims of the lab include (a) investigating genomes, transcriptomes and proteomes of neglected venomous lineages (e.g., scorpions, spiders, centipedes, jellyfish, Hymenoptera, etc.) to understand the molecular basis of venom production, regulation, and evolutionary diversification; (b) understanding the genetic basis of venom resistance in the venomous animal and its prey/predators; (c) unravelling the evolutionary forces that have shaped the current distribution of venomous animals in the Indian subcontinent, and (d) investigating the therapeutic potential of venom proteins.

Funders

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DBT-IISc Partnership Program for Advanced Research in Biological Sciences and BioEngineering

What's new?

Publication

Our paper on the comparative venomics and clinical relevance of pit viper venoms from the Western Ghats has been accepted.

 

Our paper on the origin and diversification of spider venom is online.

Distinction

Kartik has been awarded Professor Har Swarup Memorial Award from INSA

 

Senji wins the best oral presentation award for ECRs at the International Society for Toxinology 2022 in Abu Dhabi!

News

Senji and Kartik deliver talks at IST 2022, Abu Dhabi.

 

 

Kartik delivers a talk at IST Asia-Pacific Conference 2021, Cairns, Australia.

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Kartik Sunagar © 2024

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